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Pfam domain analysis
OBJECTIVE
- Pfam domains of all the current phosphoproteins in P3DB were analyzed.
Our objective is to find out whether protein phosphorylation has preference on Pfam domains.
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METHOD:
- All the oilseed rape phosphoprotein sequences are submitted to Sanger Pfam online service (Pfam 22.0)
with e-value cutoff 10-10. Then the returned result was analyzed to extract
the information on distribution of the phosphorylation sites regarding Pfam domains.
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RESULT:
- 1297 different pfam domains were found in all 6382 phosphoproteins, out of which, 712 contains phosphorylation sites.
- Overall, phosphorylation has no significant preference on pfam domains.
- In phosphorylation proteins, there are 3.8 phosphorylation sites per 1000 amino acids.
- In the domains of phosphorylation proteins, there are 3.7 phosphorylation sites per 1000 amino acids.
- Preference of protein phosphorylation towards different pfam domains varies:
phosphorylation sites per 1000 amino acids varies from 0 to 49.
- Pfam domain analysis data are available for downloading.
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